On February 15, 2016, Cha, Eunju; Kim, Sohee; Lee, Kang Mi; Kim, Ho Jun; Kim, Ki Hun; Kwon, Oh-Seung; Park, Ki Duk; Lee, Jaeick published an article.SDS of cas: 14602-86-9 The title of the article was Relationship between chromatographic resolution and amide structure of chiral 2-hydroxy acids as O-(-)-menthoxycarbonylated diastereomeric derivatives for enantiomeric separation on achiral gas chromatography. And the article contained the following:
The relation between chromatog. resolution and amide structure of chiral 2-hydroxy acids as O-(-)-menthoxycarbonylated diastereomeric derivatives on achiral gas chromatog. was studied to elucidate the best diastereomeric conformation for enantiomeric separation of chiral 2-hydroxy acids. Thirteen chiral 2-hydroxy acids were converted into nine different diastereomeric O-(-)-menthoxycarbonylated amide derivatives using the primary, secondary and cyclic amines to achieve complete enantiomeric separation through an achiral column. Each enantiomeric pair of 2-hydroxy acids as O-(-)-menthoxycarbonylated tert-butylamide derivatives was resolved on both the DB-5 and DB-17 columns with resolution factors ranging from 1.7 to 4.8 and 1.7 to 3.4, resp. The structure of the amide moiety is shown to significantly affect chromatog. resolution O-(-)-menthoxycarbonylated tert-butylamide derivatives are the best diastereomeric conformations for enantiomeric separation of 2-hydroxy acids. When comparing with the authors’ previous O-trifluoroacetylated(-)-menthyl ester derivatization method, the present results suggested that size differences between groups attached to the chiral center and conformational rigidity can have stronger effects on resolution than the distance between chiral centers. The elution of R- and S-stereoisomers was affected by the class of amine; i.e., primary, secondary, or cyclic, regardless of the substituents on the amine group, the structure of the 2-hydroxy acid, and the polarity of the column. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9
The Article related to hydroxycarboxylic acid enantiomer resolution derivation achiral gc, amide structure chiral hydroxy acid menthoxycarbonylated diastereomeric derivative gc, (−)-menthoxycarbonylated tert-butylamides, 2-hydroxy acids, enantiomeric separation and other aspects.SDS of cas: 14602-86-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics