On September 15, 2021, Chai, Xin-Yue; Xu, Hui-Bei; Dong, Lin published an article.SDS of cas: 35444-44-1 The title of the article was Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C-H Activation. And the article contained the following:
An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biol. properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C-H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Addnl., a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1
The Article related to indole preparation, acyl indole bromoalkyne alkynylation carbonylation iridium catalyst, alkynylation, carbonylation, cascade reactions, iridium, multifunctional indole derivatives, multistep c−h activation and other aspects.SDS of cas: 35444-44-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics