Crisan, Manuela; Halip, Liliana; Bourosh, Paulina; Chicu, Sergiu Adrian; Chumakov, Yurii published an article in 2017, the title of the article was Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: a combined experimental and theoretical study.COA of Formula: C7H4ClNO4 And the article contains the following content:
Background: Nitroarom. and chloronitroarom. compounds have been a subject of great interest in industry and recently in medical-pharmaceutic field. 2-Chloro-4-nitro/2-chloro-5-nitrobenzoic acids and 4-nitrobenzoic acid are promising new agents for the treatment of main infectious killing diseases in the world: immunodeficiency diseases and tuberculosis. Results: New ethanolamine nitro/chloronitrobenzoates were synthesized and characterized by X-ray crystallog., UV-vis, FT-IR and elementary anal. techniques. The toxicity of the compounds prepared and correspondent components was evaluated using Hydractinia echinata as test system. A significant lower toxicity was observed for nitroderivative compared with chloronitro-derivatives and individual components. Crystallog. studies, together with the chem. reactivity and stability profiles resulted from d. functional theory and ab initio MO calculations, explain the particular behavior of ethanolamine 4-nitrobenzoate in biol. test. Conclusions: The exptl. and theor. data reveal the potential of these compounds to contribute to the design of new active pharmaceutical ingredients with lower toxicity. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4
The Article related to ethanolamine nitro chloronitrobenzoate synthesis structure toxicity, chemical reactivity, nitrobenzoic and chloronitrobenzoic acids and derivatives, single crystal x-ray diffraction, toxicity and other aspects.COA of Formula: C7H4ClNO4
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