On July 31, 2021, Crump, Doug; Sharin, Tasnia; Chiu, Suzanne; O’Brien, Jason M. published an article.Category: chlorides-buliding-blocks The title of the article was In Vitro Screening of 21 Bisphenol A Replacement Alternatives: Compared with Bisphenol A, the Majority of Alternatives Are More Cytotoxic and Dysregulate More Genes in Avian Hepatocytes. And the article contained the following:
An avian in vitro screening approach was used to determine the effects of 21 bisphenol A (BPA) alternatives. Cytotoxicity and dysregulation of genes associated with estrogen response and other toxicol. relevant pathways evoked by these alternatives were compared with BPA. Most of the BPA alternatives (15/21) were equally or more cytotoxic than BPA in chicken embryonic hepatocytes; variability in cell viability was associated with chem. structure and the log octanol-water partition coefficient (logP) values. A neg. linear relationship (r2 = 0.745; p = 0.49-07; n = 18) was observed between logP and the log median lethal concentration (logLC50) values. The least cytotoxic BPA alternatives elicited the greatest gene dysregulation and, overall, most of the alternatives altered more genes than BPA (measured with a custom polymerase chain reaction array). This overall approach shows promise for use as a screen for hazard-based prioritization of BPA replacement alternatives and to ideally identify those that may be less harmful and/or require addnl. toxicity testing. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Category: chlorides-buliding-blocks
The Article related to gallus hepatocyte bisphenol a alternatives cytotoxicity gene expression, avian toxicity, contaminants of emerging concern, endocrine-disrupting compounds, in vitro toxicology, risk assessment and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics