On August 8, 2016, Esvan, Yannick J.; Zeinyeh, Wael; Boibessot, Thibaut; Nauton, Lionel; Thery, Vincent; Knapp, Stefan; Chaikuad, Apirat; Loaec, Nadege; Meijer, Laurent; Anizon, Fabrice; Giraud, Francis; Moreau, Pascale published an article.Recommanded Product: 99-60-5 The title of the article was Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. And the article contained the following:
The design and synthesis of new pyrido[3,4-g]quinazoline derivatives is described as well as their protein kinase inhibitory potencies toward five CMGC family members (CDK5, CK1, GSK3, CLK1 and DYRK1A). The interest for this original tricyclic heteroaromatic scaffold as modulators of CLK1/DYRK1A activity was validated by nanomolar potencies (compounds 10-nitropyrido[3,4-g]quinazolin-2-amine and Pyrido[3,4-g]quinazoline-2,10-diamine). CLK1 co-crystal structures with two inhibitors revealed the binding mode of these compounds within the ATP-binding pocket. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5
The Article related to pyridoquinazoline derivative preparation cmgc protein kinase inhibitor, clk1 pyridoquinazolineamine cocrystal structure, clk1 binding mode, cmgc family, kinase inhibitors, pyrido[3,4-g]quinazoline, ser/thr kinases and other aspects.Recommanded Product: 99-60-5
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