On July 15, 2017, Fang, Zhen; Wang, Tian-qi; Li, Hui; Zhang, Guo; Wu, Xiao-ai; Yang, Li; Peng, Yu-lan; Zou, Jun; Li, Lin-li; Xiang, Rong; Yang, Sheng-yong published an article.Application of 99-60-5 The title of the article was Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors. And the article contained the following:
Herein the authors report the discovery of a series of new small mol. inhibitors of histone lysine demethylase 4D (KDM4D). Mol. docking was first performed to screen for new KDM4D inhibitors from various chem. databases. Two hit compounds were retrieved. Further structural optimization and structure-activity relation (SAR) anal. were carried out to the more selective one, compound 5-hydroxy-9-nitropyrazolo[1,5-a]quinazoline-3-carbonitrile, which led to the discovery of several new KDM4D inhibitors. Among them, compound 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile is the most potent one with an IC50 value of 0.41 ± 0.03 μM against KDM4D. Overall, compound 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile could be taken as a good lead compound for further studies. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Application of 99-60-5
The Article related to pyrazolopyrimidinecarbonitrile derivative preparation histone lysine demethylase 4d inhibitor, epigenetics, histone lysine demethylase, kdm4d, small molecule inhibitor, structure-activity relationship and other aspects.Application of 99-60-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics