On September 4, 2020, He, Tingting; Peng, Lei; Li, Shan; Hu, Fangli; Xie, Chuandong; Huang, Shengli; Jia, Shiqi; Qin, Wenling; Yan, Hailong published an article.Product Details of 98946-18-0 The title of the article was Chiral Naphthyl-C2-Indole as Scaffold for Phosphine Organocatalysis: Application in Asymmetric Formal [4 + 2] Cycloaddition Reactions. And the article contained the following:
The applications of a newly designed chiral naphthyl-C2-indole bifunctional phosphine organocatalyst I in stereoselective formal [4 + 2] cycloaddition reactions were reported. The chiral naphthyl-C2-indole skeleton was introduced to bifunctional phosphine organocatalysis for the first time, and excellent stereocontrol was achieved in formal [4 + 2] cycloaddition reactions of dicyanomethyleneoxindoles II (R1 = Me, MeOCH2, H2C:CHCH2, PhCH2, Ph; R2 = H, 5-Me, 7-Me, 6-MeO, 6-MeO, 7-F3C, 5-Cl, 5-Br, 6-Br) with pentadienones (E)-R3CH:CHCOCH:CH2 (R3 = Ph, 4-MeC6H4, 2-MeOC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 2-furyl) and of oxoindolylideneacetates III (R4 = H, Me, MeOCH2, H2C:CHCH2, Boc, Ph, PhCH2, PhCO; R5 = H, 5-Me, 7-Me, 5, 7-Me2, 5-MeO, 6-MeO, 5-F, 5-Cl, 6-Cl, 5-Br, 6-Br, 7-Br; X = CH, N) with 3-acryloylbenzofuran. With the optimal catalyst, chiral spirooxindoles IV (R1 = Me, MeOCH2, H2C:CHCH2, PhCH2, Ph; R2 = H, 5-Me, 7-Me, 6-MeO, 6-MeO, 7-F3C, 5-Cl, 5-Br, 6-Br; R3 = Ph, 4-MeC6H4, 2-MeOC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 2-furyl) and spirodibenzofuranoxindoles V (R4 = H, Me, MeOCH2, H2C:CHCH2, Boc, Ph, PhCH2, PhCO; R5 = H, 5-Me, 7-Me, 5, 7-Me2, 5-MeO, 6-MeO, 5-F, 5-Cl, 6-Cl, 5-Br, 6-Br, 7-Br; X = CH, N) were produced in moderate to good yields with excellent stereoselectivities (up to >99% ee, >20:1 dr). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0
The Article related to phosphinoindolylnaphthol nonracemic preparation organocatalyst, spirooxindole spirodibenzofuranoxindole diastereoselective enantioselective preparation, stereoselective formal cycloaddition dicyanomethyleneoxindole pentadienone phosphinoindolylnaphthol catalyst and other aspects.Product Details of 98946-18-0
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