Komar, Mario; Kraljevic, Tatjana Gazivoda; Jerkovic, Igor; Molnar, Maja published an article in 2022, the title of the article was Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods.Electric Literature of 89-77-0 And the article contains the following content:
In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones I [R1 = H, 6-I, 6-Br, 7-Cl, 6,8-dichloro; R2 = Me, Ph, Bn, etc.] from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and Ph isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0
The Article related to mercaptoquinazolinone green preparation, anthranilic acid isothiocyanate microwave ultrasound choline chloride urea catalyst, 2-mercaptoquinazolin-4(3h)-one, deep eutectic solvents, green chemistry, microwave-assisted synthesis, ultrasound-assisted synthesis and other aspects.Electric Literature of 89-77-0
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