On June 26, 2003, Koppitz, Marcus; Muhn, Hans Peter; Shaw, Ken; Hess-Stumpp, Holger; Paulini, Klaus published a patent.Application of 59833-69-1 The title of the patent was Synthesis of tetrahydrocarbazole derivatives for use as ligands for G-protein coupled receptors and antagonists of gonadotropin-releasing hormone for treatment of disease. And the patent contained the following:
The invention relates to novel tetrahydrocarbazole derivatives [e.g., (I)] which act as ligands for G-protein coupled receptors (GPCR), especially as antagonists of gonadotropin-releasing hormone (GnRH), and pharmaceutical composition containing them. Furthermore, the invention relates to the administration of tetrahydrocarbazole derivatives for the treatment of pathol. conditions mediated by GPCR, especially for the inhibition of GnRH, to mammals, especially humans, requiring such treatment, and to the use of tetrahydrocarbazole derivatives for producing a pharmaceutical agent for treating pathol. conditions mediated by GPCR, especially for the inhibition of GnRH. Limited synthesis of intermediate materials is given, with many tables of products exemplified by general synthesis steps. Thus, beginning from 4,4-ethylenedioxycyclohexanone and phenylhydrazine, I was prepared in seven generalized steps. In in vitro tests with alpha T3-1 cells, I had IC50 for human GnRH of 1.5 x 10-8 M, with Ca2+ release of 4.5 x 10-8 M. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Application of 59833-69-1
The Article related to protein receptor antagonist tetrahydrocarbazole derivative preparation infertility conception therapy, heterocyclic compound peptide derivative preparation solid phase tumor therapy and other aspects.Application of 59833-69-1
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics