On July 1, 2021, Mezeiova, Eva; Hrabinova, Martina; Hepnarova, Vendula; Jun, Daniel; Janockova, Jana; Muckova, Lubica; Prchal, Lukas; Kristofikova, Zdena; Kucera, Tomas; Gorecki, Lukas; Chalupova, Katarina; Kunes, Jiri; Hroudova, Jana; Soukup, Ondrej; Korabecny, Jan published an article.Synthetic Route of 89-77-0 The title of the article was Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment. And the article contained the following:
The search for novel and effective therapeutics for Alzheimers disease (AD) is the main quest that remains to be resolved. The goal is to find a disease-modifying agent able to confront the multifactorial nature of the disease pos. Herewith, a family of huprineY-tryptophan heterodimers was prepared, resulting in inhibition of cholinesterase and neuronal nitric oxide synthase enzymes, with effect against amyloid-beta (Aβ) and potential ability to cross the blood-brain barrier. Their cholinesterase pattern of behavior was inspected using kinetic anal. in tandem with docking studies. These heterodimers exhibited a promising pharmacol. profile with strong implication in AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0
The Article related to hupriney tryptophan heterodimer neuroprotective agent alzheimer disease, acetylcholinesterase, alzheimer’s disease, amyloid-beta, multi-target directed ligands, huprine y, l-tryptophan and other aspects.Synthetic Route of 89-77-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics