On May 31, 2017, Nechipadappu, Sunil Kumar; Tekuri, Venkatadri; Trivedi, Darshak R. published an article.Reference of 2-Chloro-4-nitrobenzoic acid The title of the article was Pharmaceutical Co-Crystal of Flufenamic Acid: Synthesis and Characterization of Two Novel Drug-Drug Co-Crystal. And the article contained the following:
Two novel pharmaceutical co-crystals of anti-inflammatory drug flufenamic acid (FFA) with 2-chloro-4-nitrobenzoic acid (CNB) and ethenzamide (ETZ) have been synthesized by solvent evaporation method as well as by solvent drop-assisted grinding method. The synthesized co-crystals were characterized thoroughly by various spectroscopic methods and crystal structures were determined by single-crystal x-ray diffraction technique. In FFA-CNB co-crystal, robust supramol. acid-acid homosynthon was observed FFA-ETZ co-crystal is formed via robust supramol. acid-amide heterosynthon. In FTIR spectra, a significant shift in the carbonyl stretching frequency was observed for the co-crystals due to the presence of intermol. hydrogen bond. 1H NMR study suggests the presence of hydrogen bond in the solution state of FFA-ETZ co-crystal; however, it was absent for FFA-CNB co-crystal. Solubility study in Millipore water revealed that the solubility of FFA is increased by 2-fold when it is in the form of FFA-CNB co-crystal and no increment in the solubility of FFA was observed in FFA-ETZ co-crystal. About 5-fold increment in the solubility of FFA was observed in both the co-crystals in 0.1 N HCl (pH 1) solution The synthesized co-crystals were found to be non-hygroscopic at ∼75% relative humidity and stable for a period of 6 mo at ambient temperature (∼25°C). The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Reference of 2-Chloro-4-nitrobenzoic acid
The Article related to pharmaceutical solid flufenamic acid chloro nitrobenzoic acid ethenzamide cocrystal, co-crystal, crystal engineering, hygroscopicity, pharmaceutical co-crystal, solubility, stability and other aspects.Reference of 2-Chloro-4-nitrobenzoic acid
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