On November 27, 1975, Tomari, Masazumi; Miyamatsu, Hiroki; Kiyota, Keiichi; Yasuno, Akio published a patent.Product Details of 59833-69-1 The title of the patent was 2-(Alkoxycarbonylmethylphenyl)-1,3-dihydroisoindoles. And the patent contained the following:
Dihydroisoindoles I (X = H, halo; R = H, Me; R1 = C1-4 alkyl) or their salts are prepared by cyclizing o-(ClCH2)2C6H4 (II) with aminophenylacetate esters III (R2 = C1-4 alkyl). I have antiinflammatory and analgesic effects (no data). Thus, 5.24 g II was refluxed with 6 g III (X = 2-Cl, x = 5, R = H, R2 = Me) (IV) and 6.36 g Na2CO3 in DMF 4 hr to give 70% I (X = 2-Cl, x = 5, R = H, R1 = Me). The ester was hydrolyzed with KOH in MeOH to give 51.5% I (X = 2-Cl, x = 5, R = R1 = H), also prepared in 80% yield by heating II and IV with NaOH in MeOH. Similarly prepared were I (X, x, R, R1 given): 2-Cl, 5, Me, Me; 2-Cl, 5, Me, H; H, 4, H, Me; H, 4, H, H. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Product Details of 59833-69-1
The Article related to analgesic isoindole, antiinflammatory isoindole, isoindole carboxyalkylphenyl, cyclization bischloromethylbenzene carboxyalkylaniline, chloromethylbenzene dicyclization aniline, aminophenylalkanoate cyclization bischloromethylbenzene and other aspects.Product Details of 59833-69-1
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