On March 23, 2022, Varkhedkar, Rajesh; Yang, Fan; Dontha, Rakesh; Zhang, Jianglin; Liu, Jiyong; Spingler, Bernhard; van der Veen, Stijn; Duttwyler, Simon published an article.HPLC of Formula: 14602-86-9 The title of the article was Natural-Product-Directed Catalytic Stereoselective Synthesis of Functionalized Fused Borane Cluster-Oxazoles for the Discovery of Bactericidal Agents. And the article contained the following:
The identification of an alternative chem. space to address the global challenge posed by emerging antimicrobial resistance is very much needed for the discovery of novel antimicrobial lead compounds B clusters are currently being explored in drug discovery due to their unique steric and electronic properties. However, the challenges associated with the synthesis and derivatization techniques of these compounds have limited their utility in the rapid construction of a library of mols. for screening against various biol. targets as an alternative mol. platform. Herein, the authors report a transition-metal-catalyzed regioselective direct B-H alkylation-annulation of the closo-dodecaborate anion with natural products such as menthol and camphor as the directing groups. This method allowed the rapid construction of a library of 1,2,3-trisubstituted clusters, which were evaluated in terms of their antibacterial activity against WHO priority pathogens. Several of the synthesized dodecaborate derivatives displayed medium- to high-level bactericidal activity against Gram-pos. and Gram-neg. bacteria. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9
The Article related to mentholdiboraoxazole fused carborane preparation antibacterial activity, crystal structure mentholdiboraoxazole fused carborane, mol structure mentholdiboraoxazole fused carborane, rhodium catalyzed regioselective alkylation annulation dodecaborate anion styrene derivative and other aspects.HPLC of Formula: 14602-86-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics