On February 19, 2020, Wang, Ze-Shu; Chen, Yang-Bo; Zhang, Hao-Wen; Sun, Zhou; Zhu, Chunyin; Ye, Long-Wu published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines. And the article contained the following:
Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chem. can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation Moreover, such an ynamide Smiles rearrangement initiated by intermol. photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid
The Article related to cascade regioselective coupling smiles rearrangement iridium photocatalyst, benzoylbenzyl ethynylsulfonamide preparation coupling regioselective smiles rearrangement iridium photocatalyst, indole benzhydryl preparation, isoquinoline benzhydryl preparation and other aspects.Reference of 2-Amino-4-chlorobenzoic acid
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics