On March 3, 2016, Yu, Haiqing; Li, Yanxia; Ge, Yang; Song, Zhendong; Wang, Changyuan; Huang, Shanshan; Jin, Yue; Han, Xu; Zhen, Yuhong; Liu, Kexin; Zhou, Youwen; Ma, Xiaodong published an article.Computed Properties of 99-60-5 The title of the article was Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines. And the article contained the following:
With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives bearing an adamantyl group on the aniline ring were synthesized as potent epidermal growth factor receptor (EGFR) inhibitors. Most of these analogs are comparable to gefitinib in their ability to inhibit non-small cell lung cancer (NSCLC) cell lines, and several also exhibited significantly enhanced anti-tumor potency. Specifically, compound I, with an IC50 value of 2.06 μM against A431 cells with the wild-type EGFR and of 0.009 μM against the gefitinib-sensitive cells, displayed approx. 5-fold higher potency than the lead compound to inhibit the cells harboring the EGFRT790M mutant. In addition, the mol. simulation and Western blot anal. results also indicated that these compounds effectively interfered with the EGFRT790M activity, and may serve as a new alternative structure to develop more effective antitumor agents. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Computed Properties of 99-60-5
The Article related to adamantyl anilinoquinazoline preparation epidermal growth factor receptor inhibitor, egfr inhibitor adamantyl anilinoquinazoline preparation, quinazoline adamantyl preparation egfr inhibitor, adamantyl, egfr, nsclc, quinazoline, t790m and other aspects.Computed Properties of 99-60-5
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