On March 26, 2020, Asada, Masaki; Hanada, Keisuke; Higuchi, Satonori; Naganawa, Atsushi; Takeda, Yasuhiro published a patent.Application of 59833-69-1 The title of the patent was Preparation of benzamide compound as DP antagonist. And the patent contained the following:
The present invention relates to a compound I [R1 = H, alkyl or benzyl; R2-R4 = independently halo, alkyl (optionally substituted with halo) or alkoxy (optionally substituted with halo); when plural R2 or R4 groups exist, they, at each occurrence, are the same or different; J = bond, -O- or -S-; L = bond, alkylene, alkenylene, etc.; R5 = H or carbocyclyl or heterocyclyl (wherein carbocycle and heterocycle are optionally substituted with R7); when L is a bond, R5 cannot be H; R7 = halo, alkyl (optionally substituted with halo) or alkoxy (optionally substituted with halo); Q = oxygen atom or sulfur atom; R6 = H or alkyl; R11 = H, halo or alkyl (optionally substituted with halo); R12 = H, halo or alkyl (optionally substituted with halo); R11 and R12, together with the carbon atom to which they are attached, may combine to form a saturated carbocycle; n = 0-4; m = 0-3; or a pharmaceutically acceptable salt thereof]. For example, compound II was prepared via reaction of Me [4-chloro-3-(4-hydroxy-2,6-dimethylbenzamido)phenyl]acetate with N,N-bis(trifluoromethylsulfonyl)aniline and coupling reaction with 2-[(E)-3-cyclohexylpropen-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. Compound I exhibits high DP antagonistic activity, has excellent ability to migrate to the central nervous system, and therefore is useful for the treatment of disease involving DP receptors located in the central nervous system among DP-receptor-mediated diseases (i.e., sleep-wake disorder). The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Application of 59833-69-1
The Article related to benzamide preparation dp receptor antagonist, sleep wake disorder treatment benzamide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application of 59833-69-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics