On November 5, 2020, Blangetti, Marco; O’Shea, Donal F. published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Chiral auxiliary-mediated synthesis of planar chiral [2.2]metacyclophanes. And the article contained the following:
The synthesis of planar chiral [2.2]metacyclophanes, e.g., I was readily accomplished in a single synthetic step via the directed ortho metalation of a pro-chiral substituted metacyclophane. The use of (-)-menthyl chloroformate as a chiral auxiliary allowed the introduction of the useful carbonyl functional group into the aryl ring, giving access to carboxy-substituted diastereomeric mixture of planar chiral [2.2]metacyclophanes. The separation of diastereoisomers was easily accomplished by semipreparative HPLC, allowing the structural anal. of a single diastereoisomer by X-ray crystallog. and NMR spectroscopy. The structural features of the planar chiral metacyclophanes and their high inversion barriers, determined at 473 K, encourage future investigations as chiral catalysts and ligands. This synthetic route complements previously reported enantioselective synthesis by avoiding the restrictive use of (-)-sparteine as the chiral inducer. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
The Article related to planar chiral metacyclophane preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Higher-Membered Ring Systems, Including Cyclophanes and Fullerenes and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics