On December 31, 2019, Charitos, Georgios; Trafalis, Dimitrios T.; Dalezis, Panayiotis; Potamitis, Constantinos; Sarli, Vasiliki; Zoumpoulakis, Panagiotis; Camoutsis, Charalambos published an article.Name: 2-Chloro-4-nitrobenzoic acid The title of the article was Synthesis and anticancer activity of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. And the article contained the following:
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles I [R = Ph, 4-MeOC6H4CH2, PhCH:CH, Ph(CH2)3, 4-pyridinyl, etc.] has been designed, synthesized and evaluated as potential anticancer agents. The strategy of combining two chem. different but pharmacol. compatible mols. (the 1,2,4-triazole and 1,3,4-thiadiazole) in one frame has been emphasized. Several of the newly synthesized 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles I showed substantial cytostatic and cytotoxic antineoplastic activity in vitro, while they have produced relatively low acute toxicities in vivo, giving potentially high therapeutic ratios. In silico screening has revealed several protein targets including apoptotic protease-activating factor 1 (APAF1) and tyrosine-protein kinase HCK which may be involved in the biol. activities of active analogs. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Name: 2-Chloro-4-nitrobenzoic acid
The Article related to triazolothiadiazole benzyl aminosulfonyl preparation cytostatic cytotoxic antineoplastic, triazole amino mercapto condensation aromatic arylalkanoic acid, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 2-Chloro-4-nitrobenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics