Iwahashi, Maki; Takahashi, Eiji; Tanaka, Motoyuki; Matsunaga, Yoko; Okada, Yutaka; Matsumoto, Ryoji; Nambu, Fumio; Nakai, Hisao; Toda, Masaaki published an article in 2011, the title of the article was Design and synthesis of new prostaglandin D2 receptor antagonists.Safety of Methyl 2-(3-amino-4-chlorophenyl)acetate And the article contains the following content:
To identify new cost-effective prostaglandin D2 (DP) receptor antagonists, a series of novel 3-benzoylaminophenylacetic acids containing a benzoxazine moiety were synthesized and biol. evaluated. Among those tested, some representative compounds, e.g., I, were found to be orally available. Receptor selectivity and rat PK profiles were also evaluated. The structure-activity relationship (SAR) study is presented. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Safety of Methyl 2-(3-amino-4-chlorophenyl)acetate
The Article related to benzoylaminophenylacetic acid benzoxazine derivative preparation prostaglandin receptor antagonist sar, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of Methyl 2-(3-amino-4-chlorophenyl)acetate
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