Kandukuri, Sandeep R.; Jiao, Lin-Yu; Machotta, Axel B.; Oestreich, Martin published an article in 2014, the title of the article was Diastereotopic group selection in hydroxy-directed intramolecular C-H alkenylation of indole under oxidative palladium(II) catalysis.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:
Group-selective Pd(II)-catalyzed ring closures involving C-H bond alkenylation are reported. The cyclization precursors contain a prochiral bis(homoallylic) alc. unit tethered to either an arene or an indole. The homobenzylic HO group in these substrates is positioned to act as a directing group in the ortho-selective C-H bond activation prior to the cyclization event. Arene-derived precursors reacted poorly, even when applying a protocol that had proven effective in intermol. HO-directed C-H bond alkenylations. No asym. induction was obtained with chiral ligands, mono-N-protected amino acids in particular. Conversely, the cyclization of indole-derived precursors was substantially more efficient, and installation of a substituent in the benzylic position rendered these intramol. C-H bond alkenylations diastereoselective. The diastereotopic group selection is high with diastereomeric ratios ranging from dr = 91:9 to 94:6. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
The Article related to indole diastereoselective oxidative intramol carbon hydrogen alkenylation palladium catalyst, hydrocarbazole diastereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
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