On November 1, 2015, Maxson, Tucker; Bertke, Jeffery A.; Gray, Danielle L.; Mitchell, Douglas A. published an article.Quality Control of 2-Chloro-4-nitrobenzoic acid The title of the article was Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitrobenzamido)-2-hydroxypropyl]decahydroisoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitrobenzoyl)pyrrolidin-2-yl]-2-hydroxyethyl}decahydroisoquinoline-3-carboxamide. And the article contained the following:
The crystal structure and absolute configuration of the two new title nelfinavir analogs, C24H35ClN4O5, (I), and C27H39ClN4O5, (II), have been determined Each of these mols. exhibits a number of disordered moieties. There are intramol. N-H·-O hydrogen bonds in both (I) and (II). In (I) it involves the two carboxamide groups, while in (II) it involves the N-tert-Bu carboxamide group and the 2-hydroxyl O atom. The intermol. hydrogen bonding in (I) (O-H-O and N-H-O) leads to two-dimensional sheets that extend parallel to the ac plane. The intermol. hydrogen bonding in (II) (O-H-O) leads to chains that extend parallel to the a axis. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid
The Article related to nelfinavir analog crystal structure configuration, hiv protease inhibitor, absolute configuration, chiral crystal, crystal structure, nelfinavir, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics