Ramzan, Ayesha; Nazeer, Areesha; Irfan, Ahmad; Al-Sehemi, Abdullah G.; Verpoort, Francis; Khatak, Zafar A.; Ahmad, Aftab; Munawar, Munawar A.; Khan, Misbahul A.; Basra, Muhammad Asim Raza published an article in 2019, the title of the article was Synthesis and Antiplatelet Potential Evaluation of 1,3,4-Oxadiazoles Derivatives.Synthetic Route of 99-60-5 And the article contains the following content:
A novel series of 2-(3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-5-aryl-1,3,4-oxadiazoles I [R = furan-2-yl, pyridin-4-yl, 4-tolyl, etc.] were synthesized from corresponding hydrazones and evaluated their antiplatelet aggregation effect induced by arachidonic acid and collagen. Spectral data and elemental evaluation were used to confirm the structure of the compounds while mol. docking against cyclooxygenase 1 and 2 (COX1 & COX2) and quant. structure-activity relationship (QSAR) were performed in describing their antiplatelet potential. All synthesized compounds I exhibited more than 50% platelet aggregation inhibition against both arachidonic acid and collagen. Antiplatelet activities results showed that I [R = 4-nitrophenyl, furan-2-yl] compounds was highest % inhibition against arachidonic acid. High Egap and ionization potential values showed that the compound I [R = 4-bromophenyl, 4-tolyl, furan-2-yl] were supposed to be more active and good electron donor while I [R = 4-nitrophenyl, 4-fluorophenyl, 4-bromophenyl, 4-tolyl, pyridin-4-yl, 2-chloro-4-nitrophenyl] might be more active due to more electrophilic sites. Interaction with more than one residues in the binding pocket of COX-1 in comparison with aspirin and ligand efficacy (LE) consequences showed that compounds were excellent action potential for COX-1. Computational evaluations were in good agreement with antiplatelet activities of the compounds All compounds might be promising antiplatelet agents especially I [R = 4-nitrophenyl, furan-2-yl] and helpful in the synthesis of new drugs for the treatment of cardiovascular diseases (CVDs). The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5
The Article related to diphenyl pyrazolopyridinyl aryloxadiazole preparation antiplatelet activity mol docking, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Synthetic Route of 99-60-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics