On January 5, 2021, Yokoyama, Akihiro; Ishii, Arisa; Ohishi, Tomoyuki; Kikkawa, Shoko; Azumaya, Isao published an article.Synthetic Route of 99-60-5 The title of the article was Synthesis of a coronene analogue containing an amide bond by Pd-mediated intramolecular C-C bond formation of 2-halogenated 4-(alkylamino)benzoic acid cyclic trimer. And the article contained the following:
A coronene analog containing amide linkage was synthesized from a halogenated cyclic triamide by palladium-mediated intramol. C-C bond formation (I → II). The cyclic triamide was formed from the condensation of 2-chloro-4-(isobutylamino)benzoic acid in the presence of dichlorotriphenylphosphorane in 1,1,2,2-tetrachloroethane. By contrast, the condensation of 2-bromo counterpart required silicon tetrachloride in pyridine. The intramol. C-C bond formation, which yielded the target coronene analog, occurred during the reaction of bromo-substituted cyclic triamide with palladium(II) acetate, triphenylphosphine, and potassium carbonate in N,N-dimethylformamide. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5
The Article related to coronene amide synthesis palladium mediated intramol cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Synthetic Route of 99-60-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics