Zhang, Yong; Lai, Guo-Wei; Nie, Long-Jun; He, Qifang; Lin, Mei-Juan; Chi, Rong; Lu, Dong-Liang; Fan, Xiaolin published an article in 2022, the title of the article was Organocatalytic difluorobenzylation of 1,2-diketones via mild cleavage of carbon-carbon bonds.Name: 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:
α-Aryl-α,α-difluoroacetophenones (DFAPs) RCF2C(O)Ph [R = 2,4-di-O2NC6H3, 2-O2NC6H4, 3-Cl-4-O2NC6H3, etc.] were developed as a new class of difluorobenzylation reagents that could be facilely prepared from readily available and cheap starting materials. In situ carbon-carbon bond cleavage of electron-deficient DFAPs gave difluorobenzyl carbanions that underwent base-catalyzed nucleophilic addition to isatins, unsaturated-α-ketoesters and cyclic 1,2-diketones. This organocatalytic difluorobenzylation reaction provided a new and efficient protocol to prepare various valuable building blocks such as I [R1 = H, 5-F, 7-Cl, etc.; R2 = H, Me, Ph, etc.; R3 = 2,4-di-O2NC6H3, 2-O2NC6H4, 3-Cl-4-O2NC6H3, etc.] containing the electron-deficient difluorobenzyl group. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Name: 2-Chloro-4-methyl-1-nitrobenzene
The Article related to difluorobenzylated compound preparation, aryl difluoroacetophenone diketone nucleophilic difluorobenzylation dbu catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 2-Chloro-4-methyl-1-nitrobenzene
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