On December 31, 2020, Zhou, Shiyang; Huang, Gangliang published an article.Related Products of 99-60-5 The title of the article was Design, synthesis and biological evaluation of novel 7H-benzo[c][1,3]dioxolo[4,5-f]chromen-7-one derivatives with potential anti-tumor activity. And the article contained the following:
In this study, a series of novel 7H-benzo[c][1,3]dioxolo[4,5-f]chromen-7-one derivatives I (R1 = H, NH2, NO2; R2 = H, Me, Et, i-Pr, COMe) were obtained by structural modification of the lead compounds with Fissitungfine B. A total 15 compounds were designed, synthesized and evaluated as tumor inhibitors. These target compounds have the novel chem. structures that named three six-membered rings including one lactone six-membered ring. In vitro assay, the results showed that the target compounds have a broad spectrum and strong anti-tumor activity. The inhibitory activity of the compound I (R1 = NO2; R2 = i-Pr) to MCF-7 was IC50 = 0.35 +/- 0.01μM, to A-549 was IC50 = 0.37 +/- 0.01μM, to Hela was IC50 = 0.56 +/- 0.02μM, to MDC-803 was IC50 = 0.53 +/- 0.02μM and COLO-205 was IC50 = 0.50 +/- 0.02μM in vitro. At the same time, in vivo anti-tumor activity assay results showed that the target compounds had a good inhibitory effect on tumor growth. Among them, the target compound I (R1 = NO2; R2 = i-Pr) had the best anti-tumor activity, it could inhibit tumor growth well at a low dose. The target compound I (R1 = NO2; R2 = i-Pr) could be used as a candidate drug for further research and development, in order to be used as early as application in the clin. treatment of tumors. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5
The Article related to benzodioxolochromenone preparation antitumor human, anti-tumor activity, design, fissitungfine b, synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Related Products of 99-60-5
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics