On December 31, 2014, Afri, Michal; Alexenberg, Carmit; Aped, Pinchas; Bodner, Efrat; Cohen, Sarit; Ejgenburg, Michal; Eliyahu, Shlomi; Gilinsky-Sharon, Pessia; Harel, Yifat; Naqqash, Miriam E.; Porat, Hani; Ranz, Ayala; Frimer, Aryeh A. published an article.Computed Properties of 35444-44-1 The title of the article was NMR-based molecular ruler for determining the depth of intercalants within the lipid bilayer. And the article contained the following:
The development of “mol. rulers” would allow one to quant. locate the penetration depth of intercalants within lipid bilayers. To this end, an attempt was made to correlate the 13C NMR chem. shift of polarizable “reporter” carbons (e.g., carbonyls) of intercalants within DMPC liposomal bilayers – with the polarity it experiences, and with its Angstrom distance from the interface. This requires families of mols. with two “reporter carbons” separated by a known distance, residing at various depths/polarities within the bilayer. For this purpose, two homologous series of dicarbonyl compounds, Me n-oxooctadecanoates and the corresponding n-oxooctadecanoic acids (n = 4-16), were synthesized. To assist in assignment and detection several homologs in each system were prepared 13C-enriched in both carbonyls. Within each family, the number of carbons and functional groups remains the same, with the only difference being the location of the second ketone carbonyl along the fatty acid chain. Surprisingly, the head groups within each family are not anchored near the lipid-water interface, nor are they even all located at the same depth. Nevertheless, using an iterative best fit anal. of the data points enables one to obtain an exponential curve. The latter gives substantial insight into the correlation between polarity (measured in terms of the Reichardt polarity parameter, ET(30)) and penetration depth into the liposomal bilayer. Still missing from this curve are data points in the moderate polarity range. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Computed Properties of 35444-44-1
The Article related to keto ester acid mol ruler lipid bilayer nmr, (13)c nmr, dmpc, e(t), liposome, molecular ruler, oxooctadecanoates, Biochemical Methods: Spectral and Related Methods and other aspects.Computed Properties of 35444-44-1
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