On August 6, 2015, Bogdan, Andrew; Cowart, Marlon D.; Degoey, David A.; Jinkerson, Tammie K.; Koenig, John R.; Kort, Michael E.; Liu, Bo; Matulenko, Mark A.; Nelson, Derek W.; Patel, Meena V.; Peltier, Hillary; Scanio, Marc J.; Wakefield, Brian D. published a patent.Related Products of 490021-97-1 The title of the patent was Preparation of 6-heteroaryloxy- or 6-aryloxyquinoline-2-carboxamides as sodium channel blockers. And the patent contained the following:
The invention is related to the preparation of title compounds I [R1 = (un)substituted Ph, 5-6 membered heteroaryl; R2 = H, alkyl, alkoxyalkyl, etc.; R3 = H, alkenyl, haloalkyl, etc.; or R2NR3 = (un)substituted 4-8 membered monocyclic heterocycle, 6-11 membered bicyclic heterocycle, 10-12 membered tricyclic heterocycle, 7-11 membered spirocyclic heterocycle or 8-11 membered bicyclic heteroaryl comprised of a monocyclic heterocycle fused to a monocyclic heteroaryl], pharmaceutically acceptable salts, esters, amides, and radiolabeled forms that are sodium channel blockers useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. The invention is also related to pharmaceutical compositions containing I, and methods for using such compounds and compositions Thus, II was prepared by a multi-step synthesis starting from quinoline-2,6-diol. II was active in FRET-based membrane potential assays for human sodium channels Nav1.7 and Nav1.8. The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Related Products of 490021-97-1
The Article related to quinolinecarboxamide heteroaryloxy aryloxy preparation sodium channel blocker pain, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Related Products of 490021-97-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics