On December 31, 2018, Cao, Zhong-Yan; Ghosh, Tamal; Melchiorre, Paolo published an article.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Enantioselective radical conjugate additions driven by a photoactive intramolecular iminium-ion-based EDA complex. And the article contained the following:
The photochem. activity of electron donor-acceptor (EDA) complexes provides a way to generate radicals under mild conditions. This strategy has found application in chem. synthesis and recently in enantioselective catalysis. Reported methods classically relied on the formation of intermol. EDA complexes, generated upon aggregation of two suitable reagents. Herein, we further expand the synthetic utility of this strategy demonstrating that an intramol. EDA complex can trigger a photochem. catalytic enantioselective radical process. This approach enables radical conjugate additions to β-substituted cyclic enones to form quaternary carbon stereocenters with high stereocontrol using visible light irradiation Crucial for success is the use of an amine catalyst, adorned with a carbazole moiety, which generates, upon condensation with enones, chiral iminium ions that show a broad absorption band in the visible region. This optical property originates from an intramol. charge transfer π-π interaction between the electron-rich carbazole nucleus and the electron-deficient iminium double bond. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
The Article related to intramol iminium ion electron donor acceptor complex enantioselective catalysis, Placeholder for records without volume info and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
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