On January 3, 2017, Cheung, Chi Wai; Ploeger, Marten Leendert; Hu, Xile published an article.COA of Formula: C7H11ClO3 The title of the article was Direct amidation of esters with nitroarenes. And the article contained the following:
Herein, nickel-catalyzed reductive coupling of unactivated esters with nitroarenes to furnish in one step a wide range of amides bearing functional groups relevant to the development of drugs and agrochems. has been reported. The method has been used to expedite the syntheses of bio-active mols. and natural products, as well as their post-synthetic modifications. Preliminary mechanistic study indicates a reaction pathway distinct from conventional amidation methods using anilines as nitrogen sources. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3
The Article related to amide preparation, ester nitroarene reductive amidation, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C7H11ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics