On August 15, 2013, Ji, Haitao; Yu, Binxun; Zhang, Min; Guo, Wenxing published a patent.COA of Formula: C7H6ClNO2 The title of the patent was Preparation of substituted 1H-indazol-1-ol analogs as inhibitors of beta-catenin/Tcf protein-protein interactions. And the patent contained the following:
The invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analogs of formula I, synthetic methods for making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders, e.g. various tumors and cancers, associated with β-catenin/Tcf protein-protein interaction dysfunction using the compounds and compositions Compounds of formula I wherein A1 is N, NH and CR2a; A2 is N, CO, CS and CR2b; A3 is NOH and O; L is CH2, CH2CH2, CH2CH2CH2, OCH2, NHCH2, etc.; B1 is N, O and S; B2 is N, CO, CS, and SO; R11, R1b and R1c are independently H, halo, OH, NH2, C1-3 alkyl, etc.; R2a and R2b are independently H, halo, OH, NH2, C1-3 haloalkyl, etc.; and pharmaceutically acceptable salts, esters, hydrates, solvates, or polymorphs thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their inhibitory activity of β-catenin/Tcf protein-protein interaction. From the assay, it was determined that compound II exhibited Ki value of 1304 ± 2.03 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).COA of Formula: C7H6ClNO2
The Article related to substituted indazole preparation beta catenin tcf protein interaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.COA of Formula: C7H6ClNO2
Referemce:
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