On September 23, 2015, Le, Chi “Chip”; MacMillan, David W. C. published an article.Recommanded Product: Methyl 6-chloro-6-oxohexanoate The title of the article was Fragment Couplings via CO2 Extrusion-Recombination: Expansion of a Classic Bond-Forming Strategy via Metallaphotoredox. And the article contained the following:
In this study we demonstrate that mol. fragments, which can be readily coupled via a simple, in situ RO-C=OR bond-forming reaction, can subsequently undergo metal insertion-decarboxylation-recombination to generate Csp2-Csp3 bonds when subjected to metallaphotoredox catalysis. In this embodiment the conversion of a wide variety of mixed anhydrides (formed in situ from carboxylic acids and acyl chlorides) to fragment-coupled ketones is accomplished in good to high yield. A three-step synthesis of the medicinal agent edivoxetine is also described using this new decarboxylation-recombination protocol. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: Methyl 6-chloro-6-oxohexanoate
The Article related to ketone preparation, carboxylic acid acyl chloride coupling iridium nickel catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: Methyl 6-chloro-6-oxohexanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics