On August 31, 2022, Liu, Tingting; Peng, Feng; Zhu, Yunying; Cao, Xiao; Wang, Qifan; Liu, Fang; Liu, Liwei; Xue, Wei published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Design, synthesis, biological activity evaluation and mechanism of action of myricetin derivatives containing thioether quinazolinone. And the article contained the following:
Plant bacteria and viruses have a huge neg. impact on food crops in the world. Therefore, it is important to create new and efficient green pesticides. In this paper, a series of myricetin derivatives containing quinazolinone sulfide were introduced. Good antibacterial and antiviral activities of the drug mols. 2-((3-((5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-chromen-3-yl)oxy)propyl)thio)-6-fluoro-3-phenylquinazolin-4(3H)-one (T5) and 2-((4-((5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-chromen-3-yl)oxy)butyl)thio)-6-methyl-3-phenylquinazolin-4(3H)-one (T15) resp. were found by biol. activity screening. The value of dissociation constant (Kd) of compound T15 to TMV CP was 0.024 ± 0.006 μM, determined by Microscale thermophoresis (MST), which was far less than the value of 8.491 ± 2.027 μM of com. drug ningnanmycin (NNM). The interaction between compound T15 and TMV CP was further verified by mol. docking. Compound T15 formed strong hydrogen bonds with residues SER:49 and SER:15 (1.92 Å, 2.20 Å, resp.), which were superior to the traditional hydrogen bonds formed by NNM with residue SER:215 (3.64 Å). In addition, the effects of compound T15 on the contents of chlorophyll and peroxidase (POD) in tobacco were studied, and the results indicated that compound T15 could enhance the disease resistance of tobacco plants to a certain extent. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid
The Article related to thioether quinazolinone myricetin derivative mechanism antibacterial antiviral pesticide, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid
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