Mou, Xue-Qing; Chen, Xiang-Yu; Chen, Gong; He, Gang published an article in 2018, the title of the article was Radical-mediated intramolecular β-C(sp3)-H amidation of alkylimidates: facile synthesis of 1,2-amino alcohols.Recommanded Product: tert-Butyl trichloroacetimidate And the article contains the following content:
A new radical-mediated intramol. β-C(sp3)-H amidation reaction of O-alkyl trichloro- or arylimidates is reported. Various oxazolines were efficiently prepared from easily accessible alc. starting materials. The trichloro-oxazoline products can be hydrolyzed under mild conditions to give valuable 1,2-amino alcs. This amidation reaction exhibits a broad substrate scope and good functional group tolerance, and offers a powerful means for the C(sp3)-H functionalization of alcs. Mechanistic studies suggest that a sequence of 1,5-HAT of an imidate radical, iodination and cyclization might be operative. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate
The Article related to amino alc preparation alkylimidate radical intramol amidation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate
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