On January 1, 2021, Ocenasova, Lucia; Budovska, Mariana; Ocenas, Peter; Tomaskova, Natasa; Pilatova, Martina Bago; Mojzis, Jan published an article.Product Details of 14602-86-9 The title of the article was The first synthesis of natural alkaloid capparine A. And the article contained the following:
Substances containing a spirooxindole framework display important biol. activities. Natural alkaloid capparine A [(S)-(-)-1, I] has an anti-inflammatory effect. In the present study, attention has been paid to the first total synthesis of natural capparine A [(S)-(-)-1]. Racemic capparine A [(±)-1] was synthesized by bromospirocyclization of 6-methoxy-1-Boc-brassinin (II) with water, followed by oxidation of obtained spirobrassinol derivatives and removal of the Boc group. Synthesized racemic capparine A [(±)-1] was enantioresolved by derivatization with (1R,2S,5R)-menthyl chloroformate, chromatog. separation of diastereoisomers and the cleavage of the chiral auxiliary using sodium methoxide. Screening of anti-proliferative activity against human cancer cells revealed no anti-proliferative activity of the capparine A [(S)-(-)-1]. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9
The Article related to total synthesis capparine a bromospirocyclization enantioresoln, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Product Details of 14602-86-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics