Phifer, Adrienne; Gray, George; Kratchman, Jessica; Attene-Ramos, Matias S. published an article in 2021, the title of the article was Assessing how in vitro assay types predict in vivo toxicology data.Application In Synthesis of 4,4′-Sulfonylbis(chlorobenzene) And the article contains the following content:
In vivo animal bioassays are increasingly being supplemented with in vitro assays to serve as the new standard for chem. toxicity tests. Despite this shift, investigators face challenges related to increased reliance on in vitro data. The aim of this study was to deploy a streamlined method to assess the ability of in vitro data to predict similar results as in vivo data by correlating chem. toxicity rankings obtained using Benchmark Doses and Benchmark Dose Lower Limits (BMD(L)s) derived from in vivo and in vitro assays. In vitro and in vivo assay characteristics were assessed for their impact on the predictive ability of in vitro data. Min. best-fit BMD(L)s were calculated for chems. using Environmental Protection Agency′s (EPA′s) Benchmark Dose Software (BMDS). Forty-one chems. met the inclusion criteria of this study. Relative chem. toxicity rankings were assessed through Kappa statistics, Pearson correlations, and/or Ordinary Least Squares (OLS) regressions. Results illustrated likely ability of in vitro data to predict similar results as short-term in vivo data. Further, rankings derived from in vitro cytotoxicity assays, unlike stress response assays, significantly correlated with rankings derived from short-term in vivo assays. These results support the use of in vitro data as a prioritization tool within toxicity testing. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Application In Synthesis of 4,4′-Sulfonylbis(chlorobenzene)
The Article related to vitro assay type predict vivo toxicol data, in vitro, benchmark dose, benchmark dose lower limit, correlation, in vivo, Placeholder for records without volume info and other aspects.Application In Synthesis of 4,4′-Sulfonylbis(chlorobenzene)
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