Prech, Jan; Matousek, Vacla; Vaclavik, Jiri; Pechacek, Jan; Syslova, Kamila; Sot, Petr; Januscak, Jakub; Vilhanova, Beata; Kuzma, Marek; Toman, Jaromir; Kacer, Petr published an article in 2013, the title of the article was Determination of enantiomeric composition of substituted tetrahydroisoquinolines based on derivatization with menthyl chloroformate.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:
A method for the anal. of the optical purity of a series of chiral substituted tetrahydroisoquinolines (THIQs) was developed. The method is based on pre-column derivatization of the analytes with the derivatization reagent (-)-(1R)-menthyl chloroformate. The derivatization reaction selectively gives diastereomeric carbamates that are resolvable on an achiral non-polar GC column. The developed technique covers variously substituted THIQs, which differ significantly in volatility, steric and electronic properties. In all cases, the resolution factors (R) exceeded the value of 1.5. The method represents a robust way of anal. of mixtures of THIQs, which are often present in various matrixes such as body fluids, tissues and reaction mixtures The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
The Article related to enantiomer tetrahydroisoquinoline menthyl chloroformate derivatization gc ei ms, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics