On May 19, 2022, Sabbah, Dima A.; Samarat, Hla H.; Al-Shalabi, Eveen; Bardaweel, Sanaa K.; Hajjo, Rima; Sweidan, Kamal; Khalaf, Reema Abu; Al-Zuheiri, Aya M.; Abushaikha, Ghassan published an article.Name: 2-Amino-4-chlorobenzoic acid The title of the article was Design, Synthesis, and Biological Examination of N-Phenyl-6-fluoro-4-hydroxy-2-quinolone-3-carboxamides as Anticancer Agents. And the article contained the following:
Cancer is one of the leading causes of death worldwide, and it has a major impact on public health. Phosphatidylinositol 3-kinase (PI3Kα) has been recognized as a promising drug target for developing anticancer agents. Herein, a series of N-phenyl-6-fluoro-4-hydroxy-2-quinolone-3-carboxamides was developed to target PI3Kα. All synthesized compounds were characterized using FT-IR, NMR (1H and 13C) and elemental anal. All synthesized chem. analogs exerted distinctive anticancer activity. They inhibited the growth of human epithelial colorectal adenocarcinoma (Caco-2) with IC50 values between 48.63-378 μM, and human colon cancer (HCT-116) cell lines with IC50 values between 44-664 μM. Computational modeling studies provided important biol. insight. Induced-fit docking (IFD) studies showed that the synthesized chem. analogs fit the kinase catalytic domains and form a significant H-bond interaction network with key amino acids at the biding site. Furthermore, cheminformatics analyses indicated that all synthesized compounds were drug-like permitting further animal testing or clin. development. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid
The Article related to phenylfluoro hydroxyquinolone carboxamide anticancer agent clin development, Placeholder for records without volume info and other aspects.Name: 2-Amino-4-chlorobenzoic acid
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