On December 31, 2010, Sagratini, Gianni; Angeli, Piero; Buccioni, Michela; Gulini, Ugo; Marucci, Gabriella; Melchiorre, Carlo; Poggesi, Elena; Giardina, Dario published an article.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues. And the article contained the following:
Tamsulosin [I, R = Et (II)] is the most utilized α1-adrenoceptor antagonist in benign prostatic hyperplasia therapy owing to its uroselective antagonism and capability in relieving both obstructive and irritative lower urinary tract symptoms. Here, homochiral analogs I (R = i-Pr, PhCH2, CF3CH2) and III (cis-dioxane ring) were synthesized and their influence on the affinity profile for α1-adrenoceptor subtypes evaluated. Benzyl analog I (R = PhCH2) displayed a preferential antagonist profile for α1A-than α1D-and α1B-adrenoceptors, and a 12-fold higher potency at α1A-adrenoceptors with respect to the α1B subtype, and may have improved uroselectivity compared to II. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
The Article related to tamsulosin analog preparation adrenoceptor antagonist activity benign prostatic hyperplasia, Heterocyclic Compounds (More Than One Hetero Atom): Dioxanes and other aspects.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics