Shimodaira, Shingo; Iwaoka, Michio published an article in 2019, the title of the article was Synthesis of selenocysteine-containing dipeptides modeling the active site of thioredoxin reductase.Synthetic Route of 98946-18-0 And the article contains the following content:
Four cyclic dipeptides modeling the active site of thioredoxin reductase (TrxR), UU, CU, UC, and CC, where U and C represent selenocystine and cystine, resp., were synthesized and their glutathione peroxidase (GPx)-like catalytic activity was evaluated by the reaction of hydrogen peroxide (H2O2) with glutathione (GSH) in the presence of glutathione reductase (GR). Among these, only UC exhibited the significant antioxidant capacity, suggesting that an at. environment around the Se-S bond is relevant to the reactivity toward a thiol substrate. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Synthetic Route of 98946-18-0
The Article related to thioredoxin reductase trxr active site mimic cyclic dipeptide selenocysteine, Enzymes: Structure-Conformation-Active Site and other aspects.Synthetic Route of 98946-18-0
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