On May 2, 1996, Signor, Angelo; Guerrato, Alfredo; Signor, Giovanni published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of furosemide. And the patent contained the following:
Furosemide (I), known diuretic and antihypertensive agent (no data), was prepared by photochlorination of 4-chloro-2-fluoro-toluene followed by aminosulfonylation of 4-chloro-2-fluoro-benzotrichloride and condensation of 4-chloro-2-fluoro-5-(aminosulfonyl)benzoic acid with furfurylamine. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks
The Article related to furosemide preparation diuretic antihypertensive, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics