On March 15, 2010, Tamura, Satoru; Kaneko, Masafumi; Shiomi, Atsushi; Yang, Guang-Ming; Yamaura, Toshiaki; Murakami, Nobutoshi published an article.Formula: C7H11ClO3 The title of the article was Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia. And the article contained the following:
Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (1) as an unprecedented NES non-antagonistic inhibitor for nuclear export of Rev. This mechanism of action was established by competitive experiment by the biotinylated probe derived from leptomycin B, the known NES antagonistic inhibitor. Addnl., structure-activity relationship anal. by use of the synthesized analogs clarified cooperation of several functionalities in the Rev-export inhibitory activity of 1. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Formula: C7H11ClO3
The Article related to sida hydroxyoctadecadienoate inhibitor nuclear export rev protein, Plant Biochemistry: Composition and Products and other aspects.Formula: C7H11ClO3
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics