On December 31, 2015, Wang, Yang; Lei, Fan; Li, Xiaolong; He, Yi; Li, Jue; Qiu, Rui; Wu, Xueying; Hai, Li; Wu, Yong published an article.Computed Properties of 99-60-5 The title of the article was Structure-based design, synthesis and anti-influenza A virus activities of substituted phenyl-coupled heterocyclic ethylamide derivatives. And the article contained the following:
A series of new substituted phenyl-coupled heterocyclic ethylamide derivatives was designed and synthesized as anti-influenza agents. In vitro anti-influenza A(A/PR/8/34 H1N1 strain) activities of these compounds were investigated and compared to those of the com. antiviral drugs(Arbidol and Ribavirin) against the influenza. Specifically, among these twelve compounds exhibiting moderate levels of antiviral activity against influenza A, compounds 30c and 30d are the most effective ones, and as efficacious as the pos. control Ribavirin and much more effective than Ingavirin and Arbidol, indicating that they are prospective candidates for further exploration. These results are also consistent with the docking study results in terms of the design of compounds targeting influenza A via viral nucleoprotein. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Computed Properties of 99-60-5
The Article related to phenyl coupled heterocyclic ethylamide derivative antiinfluenzaa virus activity, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Computed Properties of 99-60-5
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