Wen, Hui; Qin, Wen; Yang, Guangzhong; Guo, Yanshen published an article in 2019, the title of the article was Design and synthesis of arylamidine derivatives as serotonin/norepinephrine dual reuptake inhibitors.Related Products of 99-60-5 And the article contains the following content:
To improve the in vivo antidepressant activity of previously reported serotonin (5-HT) and norepinephrine (NE) dual reuptake inhibitors, three series of arylamidine derivatives were designed and synthesized. The in vitro 5-HT and NE reuptake inhibitory activities of these compounds were evaluated, and compound II-5 was identified as the most potent 5-HT (IC50 = 620 nM) and NE (IC50 = 10 nM) dual reuptake inhibitor. Compound II-5 exhibited potent antidepressant activity in the rat tail suspension test and showed an acceptable safety profile in a preliminary acute toxicity test in mice. Our results show that these arylamidine derivatives exhibit potent 5-HT/NE dual reuptake inhibition and should be explored further as antidepressant drug candidates. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5
The Article related to arylamidine derivative serotonin norepinephrine reuptake inhibitor, antidepressant, dual reuptake inhibitors, norepinephrine, serotonin, Placeholder for records without volume info and other aspects.Related Products of 99-60-5
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