Xu, M.; Galindo-Murillo, R.; Cheatham, T. E. III; Franzini, R. M. published an article in 2017, the title of the article was Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights.COA of Formula: C11H19ClO2 And the article contains the following content:
Bioorthogonal dissociative reactions boast diverse potential applications in chem. biol. and drug delivery. The reaction of benzonorbornadienes with tetrazines to release amines from carbamate leaving groups was recently introduced as a bioorthogonal bond-cleavage reaction. The present study aimed at investigating the scope of leaving groups that are compatible with benzonorbornadienes. Synthesis of several benzonorbornadienes with different releasable groups is reported, and the reaction of these mols. with tetrazine was found to be rapid and afforded high release yields. The tetrazine-induced release of mols. proceeds in a cascade of steps including inverse-electron demand cycloaddition and cycloreversion reactions that form unstable isoindoles/isobenzofuran intermediates and spontaneously eliminate a leaving group of interest. In the case of oxygen-bridged BNBDs at room temperature, we observed the formation of an unproductive byproduct. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).COA of Formula: C11H19ClO2
The Article related to dissociative reaction benzonorbornadiene tetrazine reaction mechanism mol modeling, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C11H19ClO2
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