On September 19, 2014, Yamazoe, Sayumi; McQuade, Lindsey E.; Chen, James K. published an article.Recommanded Product: Methyl 6-chloro-6-oxohexanoate The title of the article was Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing. And the article contained the following:
Phosphorodiamidate morpholino oligonucleotides are widely used to interrogate gene function in whole organisms, and light-activatable derivatives can reveal spatial and temporal differences in gene activity. The authors describe here a new class of caged morpholino oligonucleotides that can be activated by the bacterial nitroreductase NfsB. The authors characterize the activation kinetics of these reagents in vitro and demonstrate their efficacy in zebrafish embryos that express NfsB either ubiquitously or in defined cell populations. In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: Methyl 6-chloro-6-oxohexanoate
The Article related to nitroreductase activatable caged morpholino oligonucleotide preparation gene silencing, ntla mnx1 pdx1 gene silencing nitroreductase caged morpholino oligonucleotide, Biochemical Genetics: Genetic Engineering and Cloning and other aspects.Recommanded Product: Methyl 6-chloro-6-oxohexanoate
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