Yao, Si; Zheng, Yunman; Jiang, Lijun; Xie, Chen; Wu, Fengshou; Huang, Chi; Zhang, Xiong; Wong, Ka-Leung; Li, Zaoying; Wang, Kai published an article in 2018, the title of the article was Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study.Synthetic Route of 4569-86-2 And the article contains the following content:
A methylene violet 3RAX-conjugated porphyrin has been designed and synthesized as a potential photosensitizer in photodynamic therapy because of its high DNA binding constant and the efficacy in inhibiting cancer cells with subcellular localization. At 400μM, the DNA photocleavage activities of compound 1 and2 were 80% and 20%, resp. The results fromphotophys. studies and cell experiments suggest porphyrin-methylene violet 3RAX conjugate could be developed as potential photosensitizers for mitochondrial targeting action in PDT. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Synthetic Route of 4569-86-2
The Article related to methylene violet 3rax dna photocleavage photosensitizer photodynamic therapy, Placeholder for records without volume info and other aspects.Synthetic Route of 4569-86-2
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