On December 31, 2021, Zhang, Zixue; Zhang, Qingwei; Zhang, Hao; Jiao, Minru; Guo, Zheng; Peng, Xinyan; Fu, Lei; Li, Jianqi published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities. And the article contained the following:
A series of quinazolinyl-containing benzamide derivatives were designed, synthesized and evaluated for their in vitro histone deacetylase 1 (HDAC1) inhibitory activities. Compounds 11a surpassed the known class I selective HDAC inhibitor MS-275 in both HDAC1 enzymic inhibitory activity and cellular anti-proliferative activity against a selected set of cancer cell types (Hut78, K562, Hep3B and HCT116 cells) with no observed effects on human normal cells. In particular, compound 11a inhibited HDAC1 over the other tested HDACs isoforms (HDAC2, HDAC6 and HDAC8) with acceptable safety profiles. Moreover, compound 11a displayed favorable oral pharmacokinetic properties and showed significant antitumor activity in the A549 tumor xenograft model in vivo. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid
The Article related to lung cancer hdac1 inhibitors quinazolinyl benzamide derivative, anti-proliferative activity, histone deacetylases, quinazolinyl, selectivity, tumor growth inhibition, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics