On September 6, 2017, Zhao, Wei; Wurz, Ryan P.; Peters, Jonas C.; Fu, Gregory C. published an article.Safety of Methyl 6-chloro-6-oxohexanoate The title of the article was Photoinduced, Copper-Catalyzed Decarboxylative C-N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement. And the article contained the following:
The Curtius rearrangement is a classic, powerful method for converting carboxylic acids into protected amines, but its widespread use is impeded by safety issues (the need to handle azides). We have developed an alternative to the Curtius rearrangement that employs a copper catalyst in combination with blue-LED irradiation to achieve the decarboxylative coupling of aliphatic carboxylic acid derivatives (specifically, readily available N-hydroxyphthalimide esters) to afford protected amines under mild conditions. This C-N bond-forming process is compatible with a wide array of functional groups, including an alc., aldehyde, epoxide, indole, nitroalkane, and sulfide. Control reactions and mechanistic studies are consistent with the hypothesis that copper species are engaged in both the photochem. and the key bond-forming step, which occurs through out-of-cage coupling of an alkyl radical. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Safety of Methyl 6-chloro-6-oxohexanoate
The Article related to photoinduced copper catalyzed decarboxylative c n coupling, protected amine preparation, General Organic Chemistry: Synthetic Methods and other aspects.Safety of Methyl 6-chloro-6-oxohexanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics