On January 11, 2018, Zlatopolskiy, Boris D.; Zischler, Johannes; Schaefer, Dominique; Urusova, Elizaveta A.; Guliyev, Mehrab; Bannykh, Olesia; Endepols, Heike; Neumaier, Bernd published an article.Electric Literature of 98946-18-0 The title of the article was Discovery of 7-[18F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo. And the article contained the following:
Tryptophan and its metabolites are involved in different physiol. and pathophysiol. processes. Consequently, positron emission tomog. (PET) tracers addressing tryptophan metabolic pathways should allow the detection of different pathologies like neurol. disorders and cancer. Herein we report an efficient method for the preparation of fluorotryptophans labeled in different positions with 18F and their biol. evaluation. 4-7-[18F]Fluorotryptophans ([18F]FTrps) were prepared according to a modified protocol of alc.-enhanced Cu-mediated radiofluorination in 30-53% radiochem. yields. In vitro experiments demonstrated high cellular uptake of 4-7-[18F]FTrps in different tumor cell lines. 4, 5-, And 6-[18F]FTrps, although stable in vitro, suffered from rapid in vivo defluorination. In contrast, 7-[18F]FTrp demonstrated a high in vivo stability and enabled a clear delineation of serotonergic areas and melatonin-producing pineal gland in rat brains. Moreover 7-[18F]FTrp accumulated in different tumor xenografts in a chick embryo CAM model. Thus, 7-[18F]FTrp represents a highly promising PET probe for imaging of Trp metabolism The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Electric Literature of 98946-18-0
The Article related to alc enhanced copper mediated radiofluorination radiofluorinated tryptophan preparation, pet tracer imaging tryptophan metabolism, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Electric Literature of 98946-18-0
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