Brieux, J. A.; Deulofeu, V. published an article in 1956, the title of the article was Reaction velocity of 2- and 4-chloronitrotoluenes, -anisoles and -phenetoles with piperidine in benzene.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:
cf. C.A. 46, 11126a. The velocity constant for the reaction of piperidine with the title compounds was determined at 100° by titrating potentiometrically the liberated Cl-. The equation k = t(b – 2a) ln [a(b – 2x)/b(a – x)] (a and b = initial concentrations of chloro compounds and piperidine, x = concentration of Cl- at time t) was used. Thus were determined the following (compound, k × 107 mole-1 sec.-1): 4-ClC6H4NO2, 16.8; 3,4-MeClC6H3NO2, 0;4,3-Cl(MeO)C6H3NO2, 7.0; 4,3-Cl(EtO)C6H3NO2, 4.16; 2,4-MeClC6H3NO2, 3.6; 4,2-Cl(MeO)ClC6H3NO2, 14.1; 4,2-Cl(EtO)C6H3NO2, 4.45; 2-ClC6H4NO2, 779; 2,3-ClMeC6H3-NO2, 5.55; 2,3-Cl(MeO)C6H3NO2, 152; 2,3-Cl(EtO)C6H3-NO2, 123; 2,4-ClMeC6H3NO2, 772; 2,4-Cl(MeO)C6H3NO2, 2630; 2,4-Cl(EtO)C6H3NO2, 1820; 2,5-ClMeC6H3NO2, 152; 2,5-Cl(MeO)C6H3NO2, 35.9; 2,5-Cl(EtO)C6H3NO2, 30.2, 2,6-ClMeC6H3NO2, 12.1; 2,6-Cl(MeO)C6H3NO2, 23.3; 2,6-Cl(EtO)C6H3NO2, 9.73. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene
2-Chloro-4-methyl-1-nitrobenzene(cas:38939-88-7) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics